What are they and how do they work?

Glucagon-like Peptide 1-Receptor Agonists (GLP-1 RA)

Glucose-dependent Insulinotropic Peptide (GIP)

Active Duty and Veteran Discount

〰️

Active Duty and Veteran Discount 〰️

GLP-1 Receptor Agonist 

Semaglutide (Ozempic/Wegovy)

  1. Insulin Secretion:

    GLP-1 stimulates the pancreas to release insulin, a hormone that helps lower blood sugar levels after meals. This effect is glucose-dependent, meaning it only occurs when blood sugar is elevated, reducing the risk of hypoglycemia. 

  2. Glucagon Suppression:

    GLP-1 inhibits the release of glucagon, another hormone that raises blood sugar. By suppressing glucagon, GLP-1 helps prevent excessive glucose production by the liver, further contributing to blood sugar control. 

  3. Slowing Gastric Emptying:

    GLP-1 slows down the rate at which the stomach empties food into the intestines.This delayed emptying helps to prevent rapid spikes in blood sugar levels after meals and can also contribute to feelings of fullness, potentially aiding in appetite control. 

  4. Reduced Appetite:

    GLP-1 receptor agonists have a central nervous system effect that helps to reduce food intake. By signaling the brain to feel full, they can help individuals consume fewer calories and potentially lead to weight loss. 

  5. Other Effects:

    GLP-1 receptor agonists may also have other beneficial effects, such as improved cardiovascular health and reduced triglycerides and low-density lipoprotein cholesterol. 

    (Taken from Google search)

GLP-1 Receptor Agonist

GIP                                                  

Tirzepatide (Mounjaro, Zepbound)

  1. Enhanced Insulin Secretion: Tirzepatide activates both GIP and GLP-1 receptors on pancreatic beta cells, leading to a significant increase in insulin secretion when blood sugar levels are elevated, helping to maintain glycemic control and minimize the risk of hypoglycemia.

  2. Glucagon Suppression: By activating GLP-1 receptors, Tirzepatide reduces the release of glucagon, a hormone that signals the liver to produce glucose, thus lowering hepatic glucose production and contributing to improved blood sugar levels, both fasting and postprandial.

  3. Appetite Regulation and Satiety: Tirzepatide slows gastric emptying, promotes a feeling of fullness (satiety), and influences brain areas involved in appetite regulation through GLP-1 and GIP receptor activation, reducing calorie intake and potentially leading to weight loss.

  4. Fat Metabolism and Energy Expenditure: Activation of GIP receptors by Tirzepatide has been shown to influence fat metabolism by enhancing the body's ability to break down and use stored fat for energy, which can further contribute to weight loss.

  5. Improved Insulin Sensitivity: Tirzepatide enhances insulin sensitivity in peripheral tissues, facilitating more efficient glucose uptake and utilization, which is particularly beneficial for individuals with insulin resistance, a key feature of type 2 diabetes. 

In summary, Tirzepatide's dual action on both GIP and GLP-1 receptors results in synergistic benefits, leading to improved blood sugar control, weight loss, and other metabolic improvements. 

(Taken from Google search)

What to Eat While Taking Semaglutide or Tirzepatide

To make the most of these medications and reduce the likelihood of GI side effects, your diet should emphasize nutritious, easily digestible foods.

Prioritize These Food Groups

  • High-Protein Foods: Protein supports muscle maintenance and keeps you full longer. Include lean options like chicken breasts, turkey, fish, beans, eggs, tofu, and Greek yogurt with every meal.

  • Fiber-Rich Foods: Fiber aids digestion and reduces hunger. Opt for whole grains, beans, and vegetables like leafy greens, mushrooms, and zucchini.

  • Healthy Fats: Incorporate heart-healthy fats like avocado, nuts, seeds, and olive oil to stay satiated. Seeds and nuts make for great snacks throughout the day. 

  • Low-Glycemic Index (GI) Carbs: These help maintain steady blood sugar levels. Examples include sweet potatoes, quinoa, oats, and brown rice.

  • Hydration: Drink plenty of water throughout the day to stay hydrated and support digestion.

Avoid These Foods

  • Highly Processed Foods: Chips, packaged snacks, and fast food can increase inflammation and hinder weight loss. 

    1. Sugary Drinks, Desserts, and Alcohol: High-sugar foods can cause blood sugar spikes and increase hunger. You will also want to avoid dried fruits to avoid spikes in blood sugar. Drinking alcohol can also lead to dehydration and disrupt sleep, making losing weight more challenging.

  • High-Glycemic Index (GI) Carbs: High-glycemic fruits such as pineapple, mango, bananas, and watermelon should be avoided if possible to avoid blood sugar spikes. High-glycemic veggies like starchy potatoes and sweet corn should also be reduced if not completely avoided.

  • Greasy or Fried Foods: These can aggravate GI symptoms and nausea.

  • Carbonated Beverages: Fizzy drinks may lead to bloating or discomfort.

  • They are typically given as injectable medications, usually once a week. 

  • Common side effects are fatigue, nausea, vomiting, hair loss, diarrhea and/or constipation.

  • They are not recommended for individuals with certain medical conditions such as pancreatitis or medullary thyroid cancer or those who are pregnant or breastfeeding.

  • The short answer is yes, but only under a doctor’s supervision.

Ready to get started?

Ready to get started?